Structure of PDB 5icn Chain B

Receptor sequence
>5icnB (length=369) Species: 9606 (Homo sapiens) [Search protein sequence]
RRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPH
KANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLF
EFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIV
LAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPG
TGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAV
VLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRN
VARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNE
YLEKIKQRLFENLRMLPHA
3D structure
PDB5icn Insights into the activation mechanism of class I HDAC complexes by inositol phosphates.
ChainB
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.-
3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B G27 H28 E98 D99 H140 H141 G149 F150 D176 H178 F205 G301 Y303 G20 H21 E91 D92 H133 H134 G142 F143 D169 H171 F198 G294 Y296
BS02 IHP B K31 R270 I305 K24 R263 I298
BS03 ZN B D176 H178 D264 D169 H171 D257
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity

View graph for
Molecular Function
External links
PDB RCSB:5icn, PDBe:5icn, PDBj:5icn
PDBsum5icn
PubMed27109927
UniProtQ13547|HDAC1_HUMAN Histone deacetylase 1 (Gene Name=HDAC1)

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