Structure of PDB 5iaw Chain B

Receptor sequence
>5iawB (length=227) Species: 9606 (Homo sapiens) [Search protein sequence]
LTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNH
VQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGH
SDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPD
RQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFN
HHHAEMLMSWRVNDHKFTPLLCEIWDV
3D structure
PDB5iaw A Novel Class of Natural FXR Modulators with a Unique Mode of Selective Co-regulator Assembly
ChainB
Resolution2.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B K303 H313 Q316 I317 K321 K59 H69 Q72 I73 K77
BS02 T73 B F284 L287 T288 A291 M328 I352 H447 W454 F40 L43 T44 A47 M84 I108 H203 W210
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0032052 bile acid binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0038183 bile acid signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5iaw, PDBe:5iaw, PDBj:5iaw
PDBsum5iaw
PubMed28186695
UniProtQ96RI1|NR1H4_HUMAN Bile acid receptor (Gene Name=NR1H4)

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