Structure of PDB 5i8p Chain B

Receptor sequence
>5i8pB (length=366) Species: 9606 (Homo sapiens) [Search protein sequence]
KIPRGNGPYSVGCTDLMFDHTNKGTFLRLYYPSQLDTLWIPNKEYFWGLS
KFLGTWLMGNILRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTL
YSAIGIDLASHGFIVAAVEHRDRSASATYYFKDQSAAEIGDKSWLYLRTL
KQEEETHIRNEQVRQRAKECSQALSLILDIDHGKPVKNALDLKFDMEQLK
DSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMFPLGDEVYSR
IPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTF
ATGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLI
EGDDENLIPGTNINTT
3D structure
PDB5i8p Structural and Thermodynamic Characterization of Protein-Ligand Interactions Formed between Lipoprotein-Associated Phospholipase A2 and Inhibitors
ChainB
Resolution2.37 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.1.47: 1-alkyl-2-acetylglycerophosphocholine esterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VQ7 B F110 G152 L153 S273 F274 W298 H351 Q352 A355 F357 L371 F52 G93 L94 S214 F215 W239 H292 Q293 A296 F298 L312 MOAD: Kd=0.000000064M
BindingDB: Kd=1.9nM,IC50=1.7nM
Gene Ontology
Molecular Function
GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0016787 hydrolase activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0047499 calcium-independent phospholipase A2 activity
Biological Process
GO:0009395 phospholipid catabolic process
GO:0016486 peptide hormone processing
GO:0034374 low-density lipoprotein particle remodeling
GO:0034440 lipid oxidation
GO:0034441 plasma lipoprotein particle oxidation
GO:0034638 phosphatidylcholine catabolic process
GO:0046469 platelet activating factor metabolic process
GO:0050729 positive regulation of inflammatory response
GO:0062234 platelet activating factor catabolic process
GO:0090026 positive regulation of monocyte chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0034362 low-density lipoprotein particle
GO:0034364 high-density lipoprotein particle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5i8p, PDBe:5i8p, PDBj:5i8p
PDBsum5i8p
PubMed27078579
UniProtQ13093|PAFA_HUMAN Platelet-activating factor acetylhydrolase (Gene Name=PLA2G7)

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