Structure of PDB 5i59 Chain B

Receptor sequence
>5i59B (length=275) Species: 10116 (Rattus norvegicus) [Search protein sequence]
DNHLSIVTLEEAPFVIVEDIETCVRNTVPCRKFVKINNSTNEGMNVKKCC
KGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAV
MAVGSLTINEERSEVVDFSVPFVETGISVMVSRGTQVTGLSDKKFQRPHD
YSPPFRFGTVPNGSTERNIRNNYPYMHQYMTRFNQRGVEDALVSLKTGKL
DAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQI
DLALLQFVGDGEMEELETLWLTGIC
3D structure
PDB5i59 Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.
ChainB
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLU B H88 S114 T116 R121 G172 S173 T174 Y214 H79 S105 T107 R112 G163 S164 T165 Y205
BS02 67Q B P130 F131 V132 E133 V267 E276 L280 P121 F122 V123 E124 V258 E267 L271 MOAD: ic50=641nM
PDBbind-CN: -logKd/Ki=6.95,IC50=112nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:5i59, PDBe:5i59, PDBj:5i59
PDBsum5i59
PubMed27618671
UniProtQ00959|NMDE1_RAT Glutamate receptor ionotropic, NMDA 2A (Gene Name=Grin2a)

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