Structure of PDB 5i50 Chain B

Receptor sequence
>5i50B (length=96) Species: 9606 (Homo sapiens) [Search protein sequence]
FQGAMATEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKV
VILKKATAYILSVQAETQKLISEIDLLRKQNEQLKHKLEQLRNSCA
3D structure
PDB5i50 OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors.
ChainB
Resolution2.701 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B R9 H12 N13 E16 R17 R20 P44 K45 R13 H16 N17 E20 R21 R24 P48 K49 PDBbind-CN: Kd=391nM
BS02 dna B H12 E16 R19 H16 E20 R23 PDBbind-CN: Kd=391nM
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5i50, PDBe:5i50, PDBj:5i50
PDBsum5i50
PubMed27748763
UniProtP01106|MYC_HUMAN Myc proto-oncogene protein (Gene Name=MYC)

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