Structure of PDB 5i34 Chain B

Receptor sequence
>5i34B (length=413) Species: 235443 (Cryptococcus neoformans var. grubii H99) [Search protein sequence]
SPEGVTVVLGAQWGDEGKGKLVDILAAEADICARCAGGNNAGHAFNLLPS
GLINPECTAFIGSGVVVHVPSLFNELDTLERKGLKVAGRLLVSDRAHLVM
GFHQIVDGLKEVELGGSSIGTTRKGIGPAYSSKASRSGLRVHHLFDPTFP
AKFRKLVEGRFKRYGHFEFDTEGEIEMYLAFAERLRPFIVDGPTFMHNAL
SSGKRVLVEGANALMLDLDYGTYPFVTSSSTSIGGVVSGLGISPFAIKRV
VGVIKAYTTRVGGGPFPTEDLATVGETLQEVGAEYGTVTGRRRRCGWLDL
VVMKYSTMINGYTSLNLTKLDVLDGFEEIKVATGYKIDGVEVEGFPADLD
RLAKVEVQYATLPGWKTDISNCKTYEEFPENAKAYIKFIEDYLGVKVQYV
GVGPGRDQNVIIF
3D structure
PDB5i34 Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence in Cryptococcus neoformans.
ChainB
Resolution1.53 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D18 K21 G45 H46 N229
Catalytic site (residue number reindexed from 1) D15 K18 G42 H43 N212
Enzyme Commision number 6.3.4.4: adenylosuccinate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP B G20 K21 G22 K23 G45 K336 D338 G418 G420 P421 G17 K18 G19 K20 G42 K319 D321 G401 G403 P404
BS02 IMP B D18 N43 G137 T138 T139 N229 L233 V243 T244 V278 D15 N40 G120 T121 T122 N212 L216 V226 T227 V261
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004019 adenylosuccinate synthase activity
GO:0005525 GTP binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006167 AMP biosynthetic process
GO:0044208 'de novo' AMP biosynthetic process
GO:0046040 IMP metabolic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:5i34, PDBe:5i34, PDBj:5i34
PDBsum5i34
PubMed27759389
UniProtJ9VI09

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