Structure of PDB 5hzi Chain B

Receptor sequence
>5hziB (length=476) Species: 4498,9606 [Search protein sequence]
LTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAM
IFVNWKELIMCNIKLLKALRVRKKMSGELATTLERIEKNFVITDPRLPDN
PIIFASDSFLQLTEYSREEILGRNMRFLQGPETDRATVRKIRDAIDNQTE
VTVQLINYTKSGKKFWNLFHLQPMRDQKGDVQYFIGVQLDGTEHVRDAAE
REGVMLIKKTAENIDEAAKELKMPVKMIGDILSAQLPHMQPYIRFCSRQL
NGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPL
IIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQ
AHVQCEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKSNKELYGFLFNDFL
LLTQITVFSPKSNLQYKMYKTPIFLNEVLVKLPPIFHISHIDRVYTLRAE
SINERTAWVQKIKAASELYIETEKKK
3D structure
PDB5hzi Engineering extrinsic disorder to control protein activity in living cells.
ChainB
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN B T1323 M1355 R1356 L1358 Q1359 V1368 R1372 I1375 N1387 F1399 L1401 F1414 G1416 Q1418 T93 M125 R126 L128 Q129 V138 R142 I145 N157 F169 L171 F184 G186 Q188
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0035556 intracellular signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:5hzi, PDBe:5hzi, PDBj:5hzi
PDBsum5hzi
PubMed27980211
UniProtO49003;
Q15811|ITSN1_HUMAN Intersectin-1 (Gene Name=ITSN1)

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