Structure of PDB 5hy5 Chain B

Receptor sequence
>5hy5B (length=490) Species: 67369 (Streptomyces toxytricini) [Search protein sequence]
PDKVVIVGGGTAGWMTASYLKKAFGERVSVTLVESGTIGTVGVGEATFSD
IRHFFEFLDLREEEWMPACNATYKLAVRFQDWQRPGHHFYHPFEQMRSVD
GFPLTDWWLQNGPTDRFDRDCFVMASLCDAGRSPRYLNGSLQFPYAYHFE
AALLAEFLSGYSKDRGVKHVVDEVLEVKLDDRGWISHVVTKEHGDIGGDL
FVDCTGFRGVLLNQALGVPFVSYQDTLPNDSAVALQVPLDMEARGIPPYT
RATAKEAGWIWTIPLIGRIGTGYVYAKDYCSPEEAERTLREFVGPEAADV
EANHIRMRIGRSEQSWKNNCVAIGLSSGFVEPLESTGIFFIHHAIEQLVK
HFPAGDWHPQLRAGYNSAVANVMDGVREFLVLHYLGAARNDTRYWKDTKT
RAVPDALAERIERWKVQLPDSENVFPYYHGLPPYSYMAILLGTGAIGLRP
SPALALADPAAAEKEFTAIRDRARFLVDTLPSQYEYFAAM
3D structure
PDB5hy5 A Structure-Guided Switch in the Regioselectivity of a Tryptophan Halogenase.
ChainB
Resolution2.68 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.19.59: tryptophan 6-halogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B G13 G15 A17 S40 I43 T45 V46 V48 G49 A51 V203 C233 T234 G235 W290 G353 L354 F358 P361 I367 G8 G10 A12 S35 I38 T40 V41 V43 G44 A46 V174 C204 T205 G206 W261 G324 L325 F329 P332 I338
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0004497 monooxygenase activity
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:5hy5, PDBe:5hy5, PDBj:5hy5
PDBsum5hy5
PubMed26840773
UniProtE9P162|TRP6H_STRT5 Tryptophan 6-halogenase SttH (Gene Name=sttH)

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