Structure of PDB 5hx6 Chain B

Receptor sequence
>5hx6B (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
VIKMKSSDFLESVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMN
RLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRI
ILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKL
NNEEHNELTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYEN
AIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPG
IEEKFRPFYLSQLE
3D structure
PDB5hx6 DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors.
ChainB
Resolution2.23 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D138 K140 E142 N143 D156 T189
Catalytic site (residue number reindexed from 1) D120 K122 E124 N125 D138 T159
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 65U B M44 K45 L70 V76 L78 L90 M92 L129 H136 A155 D156 L157 L159 S161 M26 K27 L52 V58 L60 L72 M74 L111 H118 A137 D138 L139 L141 S143 BindingDB: IC50=1.6nM,Ki=0.800000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5hx6, PDBe:5hx6, PDBj:5hx6
PDBsum5hx6
PubMed26854747
UniProtQ13546|RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 (Gene Name=RIPK1)

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