Structure of PDB 5ht2 Chain B

Receptor sequence
>5ht2B (length=249) Species: 10090 (Mus musculus) [Search protein sequence]
STISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVIPPYCAYL
KKRAASYTIITGNEEGYFTAILLKKGRVKFKSQEIIPFPNTKMMRNLLCV
NVSLGGNEFCLMTSHLESTREHSAERIRQLKTVLGKMQEAPDSTTVIFAG
DTNLRDQEVIKCGGLPDNVFDAWEFLGKPKHCQYTWDTKANNNLRIPAAY
KHRFDRIFFRAEEGHLIPQSLDLVGLEKLDCGRFPSDHWGLLCTLNVVL
3D structure
PDB5ht2 Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
ChainB
Resolution1.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B H236 S239 T240 R241 D272 N274 R276 W307 L315 I317 Y321 F325 H359 H115 S118 T119 R120 D151 N153 R155 W186 L194 I196 Y200 F204 H238
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:5ht2, PDBe:5ht2, PDBj:5ht2
PDBsum5ht2
PubMed27060144
UniProtQ9JJX7|TYDP2_MOUSE Tyrosyl-DNA phosphodiesterase 2 (Gene Name=Tdp2)

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