Structure of PDB 5hot Chain B

Receptor sequence
>5hotB (length=213) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
CSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLA
GRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQENPQSQGVIESMNKELKK
IIGQVRDQAEHLKTAVQMAVFIHNHKRIGGYSAGERIVDIIATDIQTKEL
QKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRR
KAKIIRDYGKQMA
3D structure
PDB5hot Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.
ChainB
Resolution4.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2SQ B L102 T124 T125 A129 W132 L47 T69 T70 A74 W77
BS02 2SQ B A169 E170 H171 T174 M178 A109 E110 H111 T114 M118
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
Biological Process
GO:0015074 DNA integration

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:5hot, PDBe:5hot, PDBj:5hot
PDBsum5hot
PubMed27935939
UniProtQ72498

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