Structure of PDB 5hn9 Chain B

Receptor sequence
>5hn9B (length=356) Species: 126793 (Plasmodium vivax Sal-1) [Search protein sequence]
LAFFRNMYDKYRDAFLSHLNEYSLEEEIKEHISKYYKLLFDYNCLGGKNN
RGILVILIYEYVKNRDINSSEWEKAACLAWCIEILQAAFLVADDIMDKGE
MRRNKYCWYLLKDVETKNAVNDVLLLYNSIYKLIEIYLRNESCYVDVIAT
FRDATLKTIIGQHLDTNIFSDKYSDAREIDVNNINVPEQPVIDINMINFG
VYKNIVIHKTAYYSFFLPIVCGMLLAGNLIYKKIEDISMLMGEYFQIHDD
YLDIFGDSTKTGKVSDIQNNKLTWPLIKTFELCSEPDKIKIVKNYGKNNL
ACVKVIDSLYEQYKIRKHYESYEKAQKAKILSAINELHHEGIEYVLKYLL
EILFTG
3D structure
PDB5hn9 Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase.
ChainB
Resolution2.12 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K81 A121 D126 D130 R135 D198 K243 F283 D287 D288
Catalytic site (residue number reindexed from 1) K48 A88 D93 D97 R102 D165 K209 F245 D249 D250
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 04W B K81 R84 Q119 F122 L123 M129 R135 R136 Q195 Y247 F283 K301 K48 R51 Q86 F89 L90 M96 R102 R103 Q162 Y213 F245 K263 MOAD: ic50=50uM
PDBbind-CN: -logKd/Ki=4.30,IC50=50uM
Gene Ontology
Molecular Function
GO:0004161 dimethylallyltranstransferase activity
GO:0004337 geranyltranstransferase activity
GO:0004659 prenyltransferase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0045337 farnesyl diphosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5hn9, PDBe:5hn9, PDBj:5hn9
PDBsum5hn9
PubMed27564465
UniProtA5K4U6

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