Structure of PDB 5hn7 Chain B

Receptor sequence
>5hn7B (length=348) Species: 126793 (Plasmodium vivax Sal-1) [Search protein sequence]
FFRNMYDKYRDAFLSHLNEYSLEEEIKEHISKYYKLLFDYNCLGGKNNRG
ILVILIYEYVINSSEWEKAACLAWCIEILQAAFLVADDIMDKGEMRRNKY
CWYLLKDVETKNAVNDVLLLYNSIYKLIEIYLRNESCYVDVIATFRDATL
KTIIGQHLDTNIFSDKYSIDVNNINVPEQPVIDINMINFGVYKNIVIHKT
AYYSFFLPIVCGMLLAGIDNLIYKKIEDISMLMGEYFQIHDDYLDIFGDS
TKTGKVSDIQNNKLTWPLIKTFELCSEPDKIKIVKNYGKNNLACVKVIDS
LYEQYKIRKHYESYEKAQKAKILSAINELHHEGIEYVLKYLLEILFTG
3D structure
PDB5hn7 Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase.
ChainB
Resolution2.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K81 A121 D126 D130 R135 D198 K243 F283 D287 D288
Catalytic site (residue number reindexed from 1) K46 A82 D87 D91 R96 D159 K199 F237 D241 D242
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 04M B G80 K81 R84 Q119 F122 A125 D126 M129 R135 R136 T191 Q195 Y247 F283 G45 K46 R49 Q80 F83 A86 D87 M90 R96 R97 T152 Q156 Y203 F237 MOAD: ic50=120uM
BS02 04M B N154 L157 N115 L118 MOAD: ic50=120uM
Gene Ontology
Molecular Function
GO:0004161 dimethylallyltranstransferase activity
GO:0004337 geranyltranstransferase activity
GO:0004659 prenyltransferase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0045337 farnesyl diphosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5hn7, PDBe:5hn7, PDBj:5hn7
PDBsum5hn7
PubMed27564465
UniProtA5K4U6

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