Structure of PDB 5hmh Chain B

Receptor sequence
>5hmhB (length=99) Species: 9606 (Homo sapiens) [Search protein sequence]
ASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLYYLGQYIMTKRLYDEK
QQHIVHCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSAGA
3D structure
PDB5hmh Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors.
ChainB
Resolution1.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 62R B K51 Y55 K31 Y35 MOAD: ic50=0.007uM
BS02 62R B Q24 L54 G58 I61 M62 Y67 Q72 F91 V93 H96 I99 Y100 Q4 L34 G38 I41 M42 Y47 Q52 F71 V73 H76 I79 Y80 MOAD: ic50=0.007uM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

View graph for
Biological Process
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Cellular Component
External links
PDB RCSB:5hmh, PDBe:5hmh, PDBj:5hmh
PDBsum5hmh
PubMed26985323
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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