Structure of PDB 5hjs Chain B

Receptor sequence
>5hjsB (length=226) Species: 9606 (Homo sapiens) [Search protein sequence]
QLSPEQLGMIEKLVAAQQLRVTPWPSREARQQRFAHFTELAIVSVQEIVD
FAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFS
YNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRP
NVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV
HSEQVFALRLQDKKLPPLLSEIWDVH
3D structure
PDB5hjs Identification and in Vivo Evaluation of Liver X Receptor beta-Selective Agonists for the Potential Treatment of Alzheimer's Disease.
ChainB
Resolution1.72 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B V105 K109 E120 I123 A124 K127 N207 P273 L274 E277 V49 K53 E64 I67 A68 K71 N151 P217 L218 E221
BS02 668 B F93 T94 L96 E103 I131 M134 T138 R141 F151 L152 L167 H257 Q260 L264 F37 T38 L40 E47 I75 M78 T82 R85 F95 L96 L111 H201 Q204 L208 BindingDB: EC50=420nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5hjs, PDBe:5hjs, PDBj:5hjs
PDBsum5hjs
PubMed27011007
UniProtQ13133|NR1H3_HUMAN Oxysterols receptor LXR-alpha (Gene Name=NR1H3)

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