Structure of PDB 5hjp Chain B

Receptor sequence
>5hjpB (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
GVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPADPASGSASQQRF
AHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETAR
RYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDA
EYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRF
PRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHEGSGSGSH
KILHRLLQD
3D structure
PDB5hjp Identification and in Vivo Evaluation of Liver X Receptor beta-Selective Agonists for the Potential Treatment of Alzheimer's Disease.
ChainB
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 668 B S242 L274 S278 E281 M312 T316 R319 F329 L330 L345 H435 W457 S26 L56 S60 E63 M94 T98 R101 F111 L112 L127 H217 W239 BindingDB: EC50=30nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5hjp, PDBe:5hjp, PDBj:5hjp
PDBsum5hjp
PubMed27011007
UniProtP55055|NR1H2_HUMAN Oxysterols receptor LXR-beta (Gene Name=NR1H2)

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