Structure of PDB 5hi4 Chain B
Receptor sequence
>5hi4B (length=91) Species:
9606
(Homo sapiens) [
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NPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDY
HMNSVPIQQEILVLRREPPNSFRLEKILVSVGCTCVTPIVH
3D structure
PDB
5hi4
Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists.
Chain
B
Resolution
1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number
?
Interaction with ligand
Site
#
Ligand
Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01
peptide
B
E60 R61 Y62 L99 R101 F110
E25 R26 Y27 L64 R66 F72
BS02
63P
B
P63 E95 I96 L97 K114
P28 E60 I61 L62 K76
Gene Ontology
Molecular Function
GO:0005125
cytokine activity
GO:0005515
protein binding
GO:0042803
protein homodimerization activity
GO:0046982
protein heterodimerization activity
Biological Process
GO:0002225
positive regulation of antimicrobial peptide production
GO:0002250
adaptive immune response
GO:0006915
apoptotic process
GO:0006954
inflammatory response
GO:0006955
immune response
GO:0007219
Notch signaling pathway
GO:0007267
cell-cell signaling
GO:0008219
cell death
GO:0009611
response to wounding
GO:0010467
gene expression
GO:0030216
keratinocyte differentiation
GO:0032731
positive regulation of interleukin-1 beta production
GO:0032735
positive regulation of interleukin-12 production
GO:0032739
positive regulation of interleukin-16 production
GO:0032747
positive regulation of interleukin-23 production
GO:0032755
positive regulation of interleukin-6 production
GO:0032760
positive regulation of tumor necrosis factor production
GO:0038173
interleukin-17A-mediated signaling pathway
GO:0043616
keratinocyte proliferation
GO:0045087
innate immune response
GO:0045672
positive regulation of osteoclast differentiation
GO:0045944
positive regulation of transcription by RNA polymerase II
GO:0050829
defense response to Gram-negative bacterium
GO:0050830
defense response to Gram-positive bacterium
GO:0050832
defense response to fungus
GO:0060729
intestinal epithelial structure maintenance
GO:0071347
cellular response to interleukin-1
GO:0072537
fibroblast activation
GO:0097400
interleukin-17-mediated signaling pathway
GO:0097530
granulocyte migration
GO:0106015
negative regulation of inflammatory response to wounding
GO:1900017
positive regulation of cytokine production involved in inflammatory response
GO:1903348
positive regulation of bicellular tight junction assembly
GO:2000340
positive regulation of chemokine (C-X-C motif) ligand 1 production
Cellular Component
GO:0005576
extracellular region
GO:0005615
extracellular space
GO:0009897
external side of plasma membrane
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:5hi4
,
PDBe:5hi4
,
PDBj:5hi4
PDBsum
5hi4
PubMed
27527709
UniProt
Q16552
|IL17_HUMAN Interleukin-17A (Gene Name=IL17A)
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