Structure of PDB 5h6v Chain B

Receptor sequence
>5h6vB (length=155) Species: 64320 (Zika virus) [Search protein sequence]
ETTDGVYRVMTRKLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRLD
PYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGIF
KTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAIT
QGKRE
3D structure
PDB5h6v Structural Dynamics of Zika Virus NS2B-NS3 Protease Binding to Dipeptide Inhibitors
ChainB
Resolution2.422 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7HS B H51 D129 Y130 S135 G151 N152 G153 Y161 H35 D113 Y114 S119 G135 N136 G137 Y145 PDBbind-CN: -logKd/Ki=6.68,IC50=208nM
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:5h6v, PDBe:5h6v, PDBj:5h6v
PDBsum5h6v
PubMed28689970
UniProtH8XX12

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