Structure of PDB 5h39 Chain B

Receptor sequence
>5h39B (length=283) Species: 37296 (Human gammaherpesvirus 8) [Search protein sequence]
PHEELQYLRQLREILCRGSDRLDRTGIGTLSLFGMQARYSLRDHFPLLTT
KRVFWRGVVQELLWFLKGSTDSRELSRTGVKIWDKNGSREFLAGRGLAHR
REGDLGPVYGFQWRHFGAAYVDADADYTGQGFDQLSYIVDLIKNNPHDRR
IIMCAWNPADLSLMALPPCHLLCQFYVADGELSCQLYQRSGDMGLGVPFN
IASYSLLTYMLAHVTGLRPGEFIHTLGDAHIYKTHIEPLRLQLTRTPRPF
PRLEILRSVSSMEEFTPDDFRLVDYCPHPTIRM
3D structure
PDB5h39 Structural Analysis of Thymidylate Synthase from Kaposi's Sarcoma-Associated Herpesvirus with the Anticancer Drug Raltitrexed.
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E111 W133 Y159 C219 R239 D242
Catalytic site (residue number reindexed from 1) E61 W83 Y109 C169 R189 D192
Enzyme Commision number 2.1.1.45: thymidylate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UMP B R199 R200 R149 R150
BS02 UMP B C219 H220 R239 S240 D242 N250 H280 Y282 C169 H170 R189 S190 D192 N200 H230 Y232
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0016741 transferase activity, transferring one-carbon groups
Biological Process
GO:0006231 dTMP biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5h39, PDBe:5h39, PDBj:5h39
PDBsum5h39
PubMed27936107
UniProtP90463|TYSY_HHV8P Thymidylate synthase (Gene Name=70)

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