Structure of PDB 5h25 Chain B

Receptor sequence
>5h25B (length=357) Species: 9606 (Homo sapiens) [Search protein sequence]
KCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYEC
HSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIIN
PITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLV
AIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKE
SYDYPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKP
GKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQV
GKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDAS
IWRWDRL
3D structure
PDB5h25 Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy
ChainB
Resolution2.88 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B W103 H104 S105 K106 D109 Y154 S159 H160 P161 R201 L246 L247 L315 G316 D317 L318 M336 F372 W373 Q374 L391 E392 E394 R420 W27 H28 S29 K30 D33 Y78 S83 H84 P85 R125 L170 L171 L232 G233 D234 L235 M253 F289 W290 Q291 L308 E309 E311 R337
BS02 LQH B F97 Y148 N194 Y365 R367 F21 Y72 N118 Y282 R284 BindingDB: IC50=6040nM
External links
PDB RCSB:5h25, PDBe:5h25, PDBj:5h25
PDBsum5h25
PubMed28092155
UniProtO75530|EED_HUMAN Polycomb protein EED (Gene Name=EED)

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