Structure of PDB 5h1u Chain B

Receptor sequence
>5h1uB (length=174) Species: 9606 (Homo sapiens) [Search protein sequence]
DWCAVCQNGGELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKP
EVEYDCDAPKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTV
PDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEP
DSEVANAGIKLENYFEELLKNLYP
3D structure
PDB5h1u The polar warhead of a TRIM24 bromodomain inhibitor rearranges a water-mediated interaction network
ChainB
Resolution1.901 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6KT B A923 F924 N980 A91 F92 N148 MOAD: Kd=63uM
PDBbind-CN: -logKd/Ki=3.51,Kd=0.31mM
BS02 ZN B C841 C844 C867 C870 C15 C18 C41 C44
BS03 ZN B C829 C832 H849 C852 C3 C6 H23 C26
External links
PDB RCSB:5h1u, PDBe:5h1u, PDBj:5h1u
PDBsum5h1u
PubMed28207202
UniProtO15164|TIF1A_HUMAN Transcription intermediary factor 1-alpha (Gene Name=TRIM24)

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