Structure of PDB 5h1t Chain B

Receptor sequence
>5h1tB (length=178) Species: 9606 (Homo sapiens) [Search protein sequence]
EDWCAVCQNGGELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSK
PEVEYDCDAPSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPV
PLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAE
FNEPDSEVANAGIKLENYFEELLKNLYP
3D structure
PDB5h1t The polar warhead of a TRIM24 bromodomain inhibitor rearranges a water-mediated interaction network
ChainB
Resolution1.951 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C829 C832 H849 C852 C4 C7 H24 C27
BS02 ZN B C841 C844 C867 C870 C16 C19 C42 C45
BS03 7FF B F924 F979 N980 V986 F96 F151 N152 V158 MOAD: Kd=0.16mM
External links
PDB RCSB:5h1t, PDBe:5h1t, PDBj:5h1t
PDBsum5h1t
PubMed28207202
UniProtO15164|TIF1A_HUMAN Transcription intermediary factor 1-alpha (Gene Name=TRIM24)

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