Structure of PDB 5gwy Chain B

Receptor sequence
>5gwyB (length=305) Species: 277944 (Human coronavirus NL63) [Search protein sequence]
LGSSGLKKMAQPSGCVERCVVRVCYGSTVLNGVWLGDTVTCPRHVIAPST
TVLIDYDHAYSTMRLHNFSVSHNGVFLGVVGVTMHGSVLRIKVSQSNVHT
PKHVFKTLKPGDSFNILACYEGIASGVFGVNLRTNFTIKGSFINGACGSP
GYNVRNDGTVEFCYLHQIELGSGAHVGSDFTGSVYGNFDDQPSLQVESAN
LMLSDNVVAFLYAALLNGCRWWLCSTRVNVDGFNEWAMANGYTSVSSVEC
YSILAAKTGVSVEQLLASIQHLHEGFGGKNILGYSSLCDEFTLAEVVKQM
YGVNL
3D structure
PDB5gwy Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design.
ChainB
Resolution2.852 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H41 G142 C144
Catalytic site (residue number reindexed from 1) H44 G145 C147
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B F139 G142 C144 H163 Q164 I165 E166 L167 G168 P189 S190 L191 F142 G145 C147 H166 Q167 I168 E169 L170 G171 P192 S193 L194
BS02 peptide B L-2 T25 V26 L1 T28 V29
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

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Molecular Function
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Biological Process
External links
PDB RCSB:5gwy, PDBe:5gwy, PDBj:5gwy
PDBsum5gwy
PubMed26948040
UniProtP0C6U6|R1A_CVHNL Replicase polyprotein 1a (Gene Name=1a)

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