Structure of PDB 5gt7 Chain B

Receptor sequence
>5gt7B (length=296) Species: 9606 (Homo sapiens) [Search protein sequence]
MELHILEHRVRVLSVARPGLWLYTHPLIKLLFLPRRSRCKFFSLTETPED
YTLMVDEEGFKELPPSEFLQVAEATWLVLNVSSHSGAAVQAAGVTKIARS
VIAPLAEHHVSVLMLSTYQTDFILVREQDLSVVIHTLAQEFDIYREVGGE
PVPGPSPTVHPIQSPQNRFCVLTLDPETLPAIATTLIDVLFYSHPSSITF
FAFSLIEGYISIVMDAETQKKFPSDLLLTSSSGELWRMVRIGGQPLGFDE
CGIVAQIAGPLAAADISAYYISTFNFDHALVPEDGIGSVIEVLQRR
3D structure
PDB5gt7 Crystal structures of arginine sensor CASTOR1 in arginine-bound and ligand free states
ChainB
Resolution2.048 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ARG B V112 L113 G274 E277 I280 V281 T300 F301 D304 V112 L113 G247 E250 I253 V254 T273 F274 D277
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0034618 arginine binding
GO:0042802 identical protein binding
GO:0140299 molecular sensor activity
GO:0140311 protein sequestering activity
Biological Process
GO:0034198 cellular response to amino acid starvation
GO:1903577 cellular response to L-arginine
GO:1904262 negative regulation of TORC1 signaling
GO:1904263 positive regulation of TORC1 signaling
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0061700 GATOR2 complex

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Biological Process
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Cellular Component
External links
PDB RCSB:5gt7, PDBe:5gt7, PDBj:5gt7
PDBsum5gt7
PubMed30503338
UniProtQ8WTX7|CAST1_HUMAN Cytosolic arginine sensor for mTORC1 subunit 1 (Gene Name=CASTOR1)

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