Structure of PDB 5gpg Chain B

Receptor sequence
>5gpgB (length=93) Species: 9606 (Homo sapiens) [Search protein sequence]
SILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETS
FNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRIS
3D structure
PDB5gpg Proximity-Directed Labeling Reveals a New Rapamycin-Induced Heterodimer of FKBP25 and FRB in Live Cells
ChainB
Resolution1.67 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RAP B L2031 S2035 R2036 F2039 T2098 D2102 Y2105 F2108 L12 S16 R17 F20 T79 D83 Y86 F89 BindingDB: IC50=>10000nM,Kd=0.600000nM
Gene Ontology
Molecular Function
GO:0044877 protein-containing complex binding

View graph for
Molecular Function
External links
PDB RCSB:5gpg, PDBe:5gpg, PDBj:5gpg
PDBsum5gpg
PubMed27610411
UniProtP42345|MTOR_HUMAN Serine/threonine-protein kinase mTOR (Gene Name=MTOR)

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