Structure of PDB 5gp1 Chain B

Receptor sequence
>5gp1B (length=260) Species: 64320 (Zika virus) [Search protein sequence]
ETLGEKWKARLNQMSALEFYSYKKSGITEVCREEARRALKDGVATGGHAV
SRGSAKLRWLVERGYLQPYGKVIDLGCGRGGWSYYAATIRKVQEVKGYTK
GGPGHEEPMLVQSYGWNIVRLKSGVDVFHMAAEPCDTLLCDIGESSSSPE
VEEARTLRVLSMVGDWLEKRPGAFCIKVLCPYTSTMMETLERLQRRYGGG
LVRVPLSRNSTHEMYWVSGAKSNTIKSVSTTSQLLLGRMDGPRRPVKYEE
DVNLGSGTRA
3D structure
PDB5gp1 Structure of the NS5 methyltransferase from Zika virus and implications in inhibitor design
ChainB
Resolution2.444 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTA B L16 N17 M19 F24 K28 S150 S151 S152 S215 T216 L11 N12 M14 F19 K23 S145 S146 S147 S210 T211
BS02 SAH B S56 G81 C82 G83 G86 T104 K105 H110 E111 D131 V132 F133 D146 S51 G76 C77 G78 G81 T99 K100 H105 E106 D126 V127 F128 D141
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5gp1, PDBe:5gp1, PDBj:5gp1
PDBsum5gp1
PubMed27866982
UniProtA0A024B7W1|POLG_ZIKVF Genome polyprotein

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