Structure of PDB 5gmf Chain B

Receptor sequence

>5gmfB (length=776) Species: 9544 (Macaca mulatta)

SPWARWFPKTLPCDVTLDVSKNHVIVDCTDKHLTEIPGGIPTNTTNLTLT
INHIPDISPASFHRLVHLVEIDFRCNCVPIRLGSKSNMCPRRLQIKPRSF
SGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKEQLTELAN
IEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTTVPTVL
PSTLTELYLYNNMIAEIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCTPC
KNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINNLQELDLSQ
NFLAKEIGDAKFLHFLPNLIQLDLSFNFELQVYRASMNLSQAFSSLKSLK
ILRIRGYVFKELKSFQLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRL
KVIDLSVNKISPVLEQLYYFRYDKYARSCRFKSCYKYGQTLDLSKNSIFF
IKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLL
HSTAFEELRKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDND
ISSSTSRTMESESLRTLEFRGNHLDVLWRDGDNRYLQLFKNLLKLEELDI
SKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFIWEKLRYLKNLETLDLS
HNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSN
KIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVQHTEVTIPY
LATDVTCVGPGAHKGQSVISLDLYTC

3D structure

• PDB: 5gmf Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA
• Chain: B
• Resolution: 2.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	B	I74 H76 C98 L105 D135 E156 Q181 Y184 R186 R467 Y468 D469 A472 R473 S474 C475	I51 H53 C75 L82 D112 E133 Q158 Y161 R163 R421 Y422 D423 A426 R427 S428 C429
BS02	GMP	B	T532 D555 L557 T586	T475 D498 L500 T529	MOAD: Kd=1uM
BS03	GMP	B	Y356 F408 K432	Y333 F385 K409	MOAD: Kd=1uM

Gene Ontology

Molecular Function

• GO:0004888 transmembrane signaling receptor activity

Biological Process

• GO:0002224 toll-like receptor signaling pathway
• GO:0006955 immune response

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:5gmf, PDBe:5gmf, PDBj:5gmf
• PDBsum: 5gmf
• PubMed: 27742543
• UniProt: B3Y653