Structure of PDB 5g4m Chain B

Receptor sequence
>5g4mB (length=197) Species: 9606 (Homo sapiens) [Search protein sequence]
SSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKLFCQLAKTCPV
QLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQH
LIRVEGNLRAEYLDDRNTFRHSVVVPCEPPEVGSDCTTIHYNYMCYSSCM
GGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENLR
3D structure
PDB5g4m Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of P53 Mutant Y220C Rescue Drugs.
ChainB
Resolution1.38 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C176 H179 C238 C242 C83 H86 C145 C149
BS02 O82 B L145 W146 V147 T150 P151 C220 E221 P222 P223 D228 T230 L52 W53 V54 T57 P58 C127 E128 P129 P130 D135 T137 MOAD: Kd=138uM
PDBbind-CN: -logKd/Ki=3.86,Kd=138uM
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006915 apoptotic process
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5g4m, PDBe:5g4m, PDBj:5g4m
PDBsum5g4m
PubMed27267810
UniProtP04637|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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