Structure of PDB 5g3w Chain B

Receptor sequence
>5g3wB (length=369) Species: 517 (Bordetella) [Search protein sequence]
HAIGYVWNTLYGWVDTGTGSLAAANLTARMQPISHHLAHPDTKRRFHELV
CASGQIEHLTPIAAVAATDADILRAHSAAHLENMKRVSNLPTGGDTGDGI
TMMGNGGLEIARLSAGGAVELTRRVATGELSAGYALVNPPGHHAPHNAAM
GFCIFNNTSVAAGYARAVLGMERVAILDWDVHHGNGTQDIWWNDPSVLTI
SLHQHLCFPPDSGYSTERGAGNGHGYNINVPLPPGSGNAAYLHAMDQVVL
PALRAYRPQLIIVGSGFDASMLDPLARMMVTADGFRQMARRTIDCAADIC
DGRIVFVQEGGYSPHYLPFCGLAVIEELTGVRSLPDPYHEFLAGMGGNTL
LDAERAAIEEIVPLLADIR
3D structure
PDB5g3w Toward Photopharmacological Antimicrobial Chemotherapy Using Photoswitchable Amidohydrolase Inhibitors.
ChainB
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B D180 H182 D268 D180 H182 D268
BS02 C65 B L21 I100 H142 H143 F152 D180 H182 F208 D268 Y312 L21 I100 H142 H143 F152 D180 H182 F208 D268 Y312 PDBbind-CN: -logKd/Ki=7.38,IC50=0.042uM
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006338 chromatin remodeling

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Molecular Function
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Biological Process
External links
PDB RCSB:5g3w, PDBe:5g3w, PDBj:5g3w
PDBsum5g3w
PubMed27756124
UniProtQ70I53|HDAH_ALCSD Histone deacetylase-like amidohydrolase (Gene Name=hdaH)

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