Structure of PDB 5g2t Chain B

Receptor sequence
>5g2tB (length=465) Species: 226186 (Bacteroides thetaiotaomicron VPI-5482) [Search protein sequence]
RQQEKPNFLIIQCDHLTQRVVGAYGQTQGCTLPIDEVASRGVIFSNAYVG
CPLSQPSRAALWSGMMPHQTNVRSNSSEPVNTRLPENVPTLGSLFSESGY
EAVHFGKTHDMGSLRGFKHKEPVAKPFTDPEFPVNNDSFLDVGTCEDAVA
YLSNPEPFICIADFQNPHNICGFIGENAGVHTDRPISGPLPELPDNFDVE
DWSNIPTPVQYICCSHRRMTQAAHWNEENYRHYIAAFQHYTKMVSKQVDS
VLKALYSTPAGRNTIVVIMADHGDGMASHRMVTKHISFYDEMTNVPFIFA
GPGIKQQKKPVDHLLTQPTLDLLPTLCDLAGIAVPAEKAGISLAPTLRGE
KQKKSHPYVVSEWHSEYEYVTTPGRMVRGPRYKYTHYLEGNGEELYDMKK
DPGERKNLAKDPKYSKILAEHRALLDDYITRSKDDYRSLKVDADPRCRNH
TPGYPSHEGPGAREI
3D structure
PDB5g2t How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans.
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D32 H33 S72 R76 K125 H127 N153 H188 D291 H292 K304
Catalytic site (residue number reindexed from 1) D14 H15 S54 R58 K107 H109 N135 H168 D271 H272 K284
Enzyme Commision number 3.1.6.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SGN B K125 R237 Y387 K107 R217 Y367
BS02 UAP B S72 N93 K125 H127 H188 C191 R238 K304 E386 Y387 S54 N75 K107 H109 H168 C171 R218 K284 E366 Y367
BS03 ZN B C233 C234 H470 H477 C213 C214 H450 H457
Gene Ontology
Molecular Function
GO:0004065 arylsulfatase activity
GO:0015024 glucuronate-2-sulfatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5g2t, PDBe:5g2t, PDBj:5g2t
PDBsum5g2t
PubMed28630303
UniProtQ8A7C8|HEXSF_BACTN Delta 4,5-hexuronate-2-O-sulfatase (Gene Name=BT_1596)

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