Structure of PDB 5g11 Chain B

Receptor sequence
>5g11B (length=375) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
RRTAFFFDELCLWHAAGPHALTLPVGGWVQPPAAAGHAESPETKRRLKSL
LDVSGLTARLQLRSAPPASDEDLLRVHPAHYLERFKALSDAGGGSLGQDA
PIGPGSYEIARLSAGLAIAALDAVLAGEADNAYSLSRPPGHHCLPDQAMG
FCFFANIAVAIEAAKARHGVERVAVLDWDVHHGNGTQAIYYRRDDVLSIS
LHQDGCFPPGYSGAEDIGEDRGRGFNLNVPLLPGGGHDAYMQAMQRIVLP
ALERFRPQLIVVASGFDANAVDPLARMQLHSDSFRAMTAMVRDAAERHAG
GRLVVVHEGGFSEAYVPFCGLAVIEELSGVRSAVRDPLRDFIELQQPNAA
FRDFQRQRLEELAAQFGLCPAQPLQ
3D structure
PDB5g11 Crystal Structure of a Histone Deacetylase Homologue from Pseudomonas aeruginosa.
ChainB
Resolution2.48 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7H1 B T24 D101 H143 H144 G152 F153 D181 H183 F209 L276 T22 D99 H141 H142 G150 F151 D179 H181 F207 L274 MOAD: ic50=62nM
PDBbind-CN: -logKd/Ki=7.21,IC50=62nM
BS02 ZN B D181 H183 D269 D179 H181 D267
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0040029 epigenetic regulation of gene expression

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Molecular Function
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Biological Process
External links
PDB RCSB:5g11, PDBe:5g11, PDBj:5g11
PDBsum5g11
PubMed27951649
UniProtQ9HXM1|HDAH_PSEAE Histone deacetylase-like amidohydrolase (Gene Name=PA3774)

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