Structure of PDB 5g10 Chain B

Receptor sequence
>5g10B (length=376) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
TRRTAFFFDELCLWHAAGPHALTLPVGGWVQPPAAAGHAESPETKRRLKS
LLDVSGLTARLQLRSAPPASDEDLLRVHPAHYLERFKALSDAGGGSLGQD
APIGPGSYEIARLSAGLAIAALDAVLAGEADNAYSLSRPPGHHCLPDQAM
GFCFFANIAVAIEAAKARHGVERVAVLDWDVHHGNGTQAIYYRRDDVLSI
SLHQDGCFPPGYSGAEDIGEDRGRGFNLNVPLLPGGGHDAYMQAMQRIVL
PALERFRPQLIVVASGFDANAVDPLARMQLHSDSFRAMTAMVRDAAERHA
GGRLVVVHEGGYSEAYVPFCGLAVIEELSGVRSAVRDPLRDFIELQQPNA
AFRDFQRQRLEELAAQFGLCPAQPLQ
3D structure
PDB5g10 Crystal Structure of a Histone Deacetylase Homologue from Pseudomonas aeruginosa.
ChainB
Resolution1.71 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6DK B L340 F343 L339 F342 MOAD: ic50=9.7nM
PDBbind-CN: -logKd/Ki=8.01,IC50=9.7nM
BS02 ZN B D181 H183 D269 D180 H182 D268
BS03 6DK B T24 D101 H143 H144 G152 F153 D181 H183 F209 E310 G311 Y313 T23 D100 H142 H143 G151 F152 D180 H182 F208 E309 G310 Y312 MOAD: ic50=9.7nM
PDBbind-CN: -logKd/Ki=8.01,IC50=9.7nM
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0040029 epigenetic regulation of gene expression

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Molecular Function
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Biological Process
External links
PDB RCSB:5g10, PDBe:5g10, PDBj:5g10
PDBsum5g10
PubMed27951649
UniProtQ9HXM1|HDAH_PSEAE Histone deacetylase-like amidohydrolase (Gene Name=PA3774)

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