Structure of PDB 5fym Chain B

Receptor sequence
>5fymB (length=446) Species: 9606 (Homo sapiens) [Search protein sequence]
DKLNPPTPSIYLENKRDAFFPPLHQFCTNPKNPVTVIRGLAGALKLDLGL
FSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWRCESNRSHTTIA
KYAQYQASSFQESLREENEPFKTIKFGTNIDLSDNKKWKLQLHELTKLPA
FARVVSAGNLLTHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNIN
IGPGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSWWPNLEDLYEANVPVY
RFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNVGPLTACQYKLAVERYEW
NKLKSVKSPVPMVHLSWNMARNIKVSDPKLFEMIKYCLLKILKQYQTLRE
ALVAAGKEVIWHGRTNDEPAHYCSICEVEVFNLLFVTNESNTQKTYIVHC
HDCARKTSKSLENFVVLEQYKMEDLIQVYDQFTLALSLSSSSAENL
3D structure
PDB5fym Crystal Structure of Jmjc Domain of Human Histone Demethylase Uty in Complex with D-2- Hydroxyglutarate
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.68: [histone H3]-trimethyl-L-lysine(27) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN B H1014 E1016 H1094 H188 E190 H268
BS02 2HG B K1005 T1011 H1014 S1022 N1024 W1034 K179 T185 H188 S196 N198 W208
BS03 ZN B C1199 C1202 C1226 C1229 C373 C376 C400 C403
External links
PDB RCSB:5fym, PDBe:5fym, PDBj:5fym
PDBsum5fym
PubMed
UniProtO14607|UTY_HUMAN Histone demethylase UTY (Gene Name=UTY)

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