Structure of PDB 5fwj Chain B

Receptor sequence
>5fwjB (length=429) Species: 9606 (Homo sapiens) [Search protein sequence]
SMFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPP
FAVEVDNFRFTPRIQRLNELTREYTLQSFGEMADSFKADYFNMPVHMVPT
ELVEKEFWRLVNSIEEDVTVEYGADIHSKEFGSGFPVSTPEEEEYATSGW
NLNVMPVLEQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSIN
YLHWGEPKTWYGVPSLAAEHLEEVMKKLTLMNPNTLMSHGVPVVRTNQCA
GEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYC
VFSHEELICKMAACPEKLDLNLAAAVHKEMFIMVQEERRLRKALLEKGIT
EAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKC
SSSRQYLRYRYTLDELPAMLHKLKVRAES
3D structure
PDB5fwj Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
ChainB
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G496 Y503 H514 E516 H602 A614
Catalytic site (residue number reindexed from 1) G172 Y179 H190 E192 H262 A274
Enzyme Commision number 1.14.11.67: [histone H3]-trimethyl-L-lysine(4) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C707 C710 C730 H733 C367 C370 C390 H393
BS02 ZN B C721 C724 C738 C740 C381 C384 C398 C400
BS03 MN B H514 E516 H602 H190 E192 H262
BS04 MG B R634 R637 H733 R294 R297 H393
BS05 MG B P624 K668 P284 K328
BS06 MMK B Y440 D443 W501 Y503 F511 H514 E516 K532 W534 H602 V615 N616 Y122 D125 W177 Y179 F187 H190 E192 K208 W210 H262 V275 N276 MOAD: Ki=0.0061uM
External links
PDB RCSB:5fwj, PDBe:5fwj, PDBj:5fwj
PDBsum5fwj
PubMed27214403
UniProtP41229|KDM5C_HUMAN Lysine-specific demethylase 5C (Gene Name=KDM5C)

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