Structure of PDB 5fs7 Chain B

Receptor sequence
>5fs7B (length=449) Species: 9606 (Homo sapiens) [Search protein sequence]
KAPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLS
KELWFSDDPNVTKTLRFKQWNGKERSIYFQPPSFYVSAQDLPHIENGGVA
VLTGKKVVQLDVRDNMVKLNDGSQITYEKCLIATGSTPRSLSAIDRAGAE
VKSRTTLFRKIGDFRSLEKISREVKSITIIGGGFLGSELACALGRKARAL
GTEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSS
GKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAE
LQARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPY
WHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATYGKGV
IFYLRDKVVVGIVLWNIFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED
3D structure
PDB5fs7 Structure/Function Relations in Aifm1 Variants Associated with Neurodegenerative Disorders.
ChainB
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.6.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B G138 G139 G140 T141 A142 E164 D165 R172 P173 K177 K232 V233 T260 F284 R285 N403 G437 D438 E453 H454 H455 A458 W483 G12 G13 G14 T15 A16 E38 D39 R46 P47 K51 K106 V107 T134 F158 R159 N277 G311 D312 E327 H328 H329 A332 W357
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0046983 protein dimerization activity

View graph for
Molecular Function
External links
PDB RCSB:5fs7, PDBe:5fs7, PDBj:5fs7
PDBsum5fs7
PubMed27178839
UniProtO95831|AIFM1_HUMAN Apoptosis-inducing factor 1, mitochondrial (Gene Name=AIFM1)

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