Structure of PDB 5foo Chain B

Receptor sequence

>5fooB (length=463) Species: 160490 (Streptococcus pyogenes M1 GAS)

MLAFPKEFWWGGATSGPQSEGRFAKQHRNLFDYWYEEEPDLFYDYVGPDT
ASDAYHQIESDLTLLASLGHNSYRTSIQWTRLIDDFEQATINPDGLAYYN
RVIDACLANGIRPVINLHHFDLPIALYQAYGGWESKHVVDLFVAFSKVCF
EQFGDRVKDWFVHNEPMVVVEGSYLMQFHYPAIVDGKKAVQVAYNLALAT
AKVIQAYRRGPAELSDGRIGTILNLTPAYPASQSEADMAAAHFAELWNND
LFMEAAVHGKFPEELVAVLKKDGVLWQSTPEELALIAENRVDYLGLNFYH
PKRVKAPDAIPVISPSWSPEWYYDPYLMPGHRMNVDKGWEIYPEAVYDIA
IKMRDHYDNIPWFLSENGVGISGEDRYRDETGQIQDDYRIQFLKEHLTYL
HKGIEAGSNCFGYHVWTPIDGWSWLNAYKNRYGLVENNIHTQVRRPKASA
YWFKKVATHNRLI

3D structure

• PDB: 5foo Chemoenzymatic Synthesis of 6-Phospho-Cyclophellitol as a Novel Probe of 6-Phospho-Beta-Glucosidases.
• Chain: B
• Resolution: 2.1 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): R74 H119 E165 V168 N297 Y299 E366
• Catalytic site (residue number reindexed from 1): R74 H119 E165 V168 N297 Y299 E366
• Enzyme Commision number: '3.2.1.21
  3.2.1.86'

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	JAZ	B	Q18 H119 Y299 K337 E366 W416 S423 W424 Y432	Q18 H119 Y299 K337 E366 W416 S423 W424 Y432

Gene Ontology

Molecular Function

• GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
• GO:0008422 beta-glucosidase activity
• GO:0016798 hydrolase activity, acting on glycosyl bonds

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0016052 carbohydrate catabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:5foo, PDBe:5foo, PDBj:5foo
• PDBsum: 5foo
• PubMed: 26790390
• UniProt: Q99YP9