Structure of PDB 5fno Chain B

Receptor sequence

>5fnoB (length=568) Species: 318829 (Pyricularia oryzae)

VVYTLPCEDGNSTARTAEIRLKQATLLYGPSLLGNASYFPGGPLGDAISL
RDQTVWEGAAVVQSLRAFTDAAKVAANIKQNGGLNSLDDFKVLYQDGWKG
SVPQGIARGQSENYTSDLLFSMERLSVNPYILKRLHPTEDALPFQVDRAT
VKQLTKTSLKALHAAGRLFVADHSYQRNYTRLANRYSAACTALFYLDPRS
NQFLPLAIKTNVGADLTYTPLDTDNNNWLLAKIMFNNNDLFHGQIFHVAY
PHAIAEIVHLAALRTMSARHPVLALMERLMYQAYAVRPLGERVLFNKGGL
FEQNFAYPQDMVYKFVGDSYPTTGRWRAGYLDTDVRARGLVDADYGPELP
HFPFYEDGSRLVEVIRRFVRSFVDATYHESDEMVAKDAELQAWVAEANGP
AGVEDFEPGPLDTRERLVEVLTHMAWLTGCAHHVLNQGEPVTASGVLPMH
PTALYAPVPTSKANTTADLLGYLPSAQKSVDQVTLLARFNRPDVVPTNQT
LRYMFAAPQLLLGNGEAYRRANQRFVRAMGRISDEVKARRFDDRGLSQGM
PFIWQALDPGNIPFYLSV

3D structure

• PDB: 5fno Crystal Structure of Manganese Lipoxygenase of the Rice Blast Fungus Magnaporthe Oryzae
• Chain: B
• Resolution: 2.038 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H284 H289 H469 N473
• Catalytic site (residue number reindexed from 1): H247 H252 H432 N436
• Enzyme Commision number: 1.13.11.-
  1.13.11.45: linoleate 11-lipoxygenase.
  1.13.11.58: linoleate 9S-lipoxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MN	B	H284 H289 H469 N473 V605	H247 H252 H432 N436 V568

Gene Ontology

Molecular Function

• GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
• GO:0046872 metal ion binding
• GO:0050584 linoleate 11-lipoxygenase activity
• GO:0051213 dioxygenase activity
• GO:1990136 linoleate 9S-lipoxygenase activity

Biological Process

• GO:0034440 lipid oxidation
• GO:0043651 linoleic acid metabolic process

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:5fno, PDBe:5fno, PDBj:5fno
• PDBsum: 5fno
• PubMed: 26783260
• UniProt: G4NAP4|MNLOX_PYRO7 Manganese lipoxygenase (Gene Name=MGG_08499)