Structure of PDB 5fn0 Chain B

Receptor sequence
>5fn0B (length=455) Species: 294 (Pseudomonas fluorescens) [Search protein sequence]
NARQVTIIGAGLAGTLVARLLARNGWQVNLFERRPDPRIETGARGRSINL
ALAERGAHALRLAGLEREVLAEAVMMRGRMVHVPGTPPNLQPYGRDDSEV
IWSINRDRLNRILLDGAEAAGASIHFNLGLDSVDFARQRLTLSNVSGERL
EKRFHLLIGADGCNSAVRQAMASVVDLGEHLETQPHGYKELQITPEASAQ
FNLEPNALHIWPHGDYMCIALPNLDRSFTVTLFLHHQSPAAQPASPSFAQ
LVDGHAARRFFQRQFPDLSPMLDSLEQDFEHHPTGKLATLRLTTWHVGGQ
AVLLGDAAHPMVPFHGQGMNCALEDAVALAEHLQSAADNASALAAFTAQR
QPDALAIQAMALENYVEMSSKVASPTYLLERELGQIMAQRQPTRFIPRYS
MVTFSRLPYAQAMARGQIQEQLLKFAVANHSDLTSINLDAVEHEVTRCLP
PLSHL
3D structure
PDB5fn0 Kynurenine-3-Monooxygenase Inhibition Prevents Multiple Organ Failure in Rodent Models of Acute Pancreatitis.
ChainB
Resolution3.19 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.13.9: kynurenine 3-monooxygenase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004497 monooxygenase activity
GO:0004502 kynurenine 3-monooxygenase activity
GO:0016174 NAD(P)H oxidase H2O2-forming activity
GO:0050660 flavin adenine dinucleotide binding
GO:0071949 FAD binding
Biological Process
GO:0006569 tryptophan catabolic process
GO:0009435 NAD biosynthetic process
GO:0019363 pyridine nucleotide biosynthetic process
GO:0019674 NAD metabolic process
GO:0019805 quinolinate biosynthetic process
GO:0034354 'de novo' NAD biosynthetic process from tryptophan
GO:0043420 anthranilate metabolic process
GO:0070189 kynurenine metabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5fn0, PDBe:5fn0, PDBj:5fn0
PDBsum5fn0
PubMed26752518
UniProtQ84HF5|KMO_PSEFL Kynurenine 3-monooxygenase (Gene Name=kmo)

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