Structure of PDB 5fdx Chain B

Receptor sequence
>5fdxB (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
FPRSRLRFKEKLGEGQFGEVHLCEVDSPLLVAVKILRPDATKNARNDFLK
EVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDK
AGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIA
DFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTL
WEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYEL
MLRCWSRESEQRPPFSQLHRFLAE
3D structure
PDB5fdx Structure of DDR1 receptor tyrosine kinase in complex with D2164 inhibitor at 2.65 Angstroms resolution.
ChainB
Resolution2.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D766 R770 N771 D784
Catalytic site (residue number reindexed from 1) D133 R137 N138 D151
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5X1 B A653 K655 E672 M676 L679 I685 M699 T701 D702 Y703 M704 H764 A783 D784 A32 K34 E51 M55 L58 I64 M78 T80 D81 Y82 M83 H131 A150 D151 BindingDB: IC50=66.2nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5fdx, PDBe:5fdx, PDBj:5fdx
PDBsum5fdx
PubMed
UniProtQ08345|DDR1_HUMAN Epithelial discoidin domain-containing receptor 1 (Gene Name=DDR1)

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