Structure of PDB 5fa6 Chain B

Receptor sequence

>5fa6B (length=602) Species: 9606 (Homo sapiens) [Search protein sequence]

SSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEE
YDLADLSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDWLQETDVDLSGV
KFAVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDF
ITWREQFWPAVCEHFGVEATSIRQYELVVHTDIDAAKVYMGEMGRLKSYE
NQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHV
AVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNKKHPFPCPTSYRTA
LTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWV
VEARRHILAILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVH
ICAVVVEYETKAGRINKGVATNWLRAKEPARALVPMFVRKSQFRLPFKAT
TPVIMVGPGTGVAPFIGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLY
REELAQFHRDGALTQLNVAFSREQSHKVYVQHLLKQDREHLWKLIEGGAH
IYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVDYIKKLMTKGRYSLDV
WS

3D structure

PDB

5fa6 Instability of the Human Cytochrome P450 Reductase A287P Variant Is the Major Contributor to Its Antley-Bixler Syndrome-like Phenotype.

Chain

Resolution

2.3 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	Y459 S460 C632 D677 W679
Catalytic site (residue number reindexed from 1)	Y386 S387 C554 D599 W601
Enzyme Commision number	1.6.2.4: NADPH--hemoprotein reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FMN	B	S89 Q90 T91 T93 A94 T142 Y143 G144 L176 G177 N178 Y181	S20 Q21 T22 T24 A25 T73 Y74 G75 L107 G108 N109 Y112
BS02	FAD	B	R427 R457 Y458 Y459 S460 C475 A476 V479 Y481 G491 V492 A493 T494 W679	R354 R384 Y385 Y386 S387 C402 A403 V406 Y408 G418 V419 A420 T421 W601
BS03	NAP	B	R301 G537 T538 C569 S599 R600 K605 Y607 Q609 M638	R228 G459 T460 C491 S521 R522 K527 Y529 Q531 M560	MOAD: Ki=16.1uM

Gene Ontology

	Molecular Function
GO:0003958	NADPH-hemoprotein reductase activity
GO:0005515	protein binding
GO:0010181	FMN binding
GO:0016491	oxidoreductase activity
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

	Biological Process
GO:0006805	xenobiotic metabolic process
GO:0009725	response to hormone
GO:0022900	electron transport chain
GO:0032770	positive regulation of monooxygenase activity
GO:0090346	cellular organofluorine metabolic process

	Cellular Component
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle

View graph for
Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:5fa6, PDBe:5fa6, PDBj:5fa6
PDBsum	5fa6
PubMed	27496950
UniProt	P16435\|NCPR_HUMAN NADPH--cytochrome P450 reductase (Gene Name=POR)

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