Structure of PDB 5f6c Chain B

Receptor sequence
>5f6cB (length=510) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
HMKRMLINATQQEELRVALVDGQRLYDLDIESPGHEQKKANIYKGKITRI
EPSLEAAFVDYGAERHGFLPLKEIAREYFPANYSAHGRPNIKDVLREGQE
VIVQIDKEERGNKGAALTTFISLAGSYLVLMPNNPRAGGISRRIEGDDRT
ELKEALASLELPEGMGLIVRTAGVGKSAEALQWDLSFRLKHWEAIKKAAE
SRPAPFLIHQESNVIVRAFRDYLRQDIGEILIDNPKVLELARQHIAALGR
PDFSSKIKLYTGEIPLFSHYQIESQIESAFQREVRLPSGGSIVIDSTEAL
TAIRINSARATRGGDIEETAFNTNLEAADEIARQLRLRDLGGLIVIRFID
MTPVRHQRAVENRLREAVRQDRARIQISHISRFGLLEMSRQRLSPSLGES
SHHVCPRCSGTGTVRDNESLSLSILRLIEEEALKENTQEVHAIVPVPIAS
YLLNEKRSAVNAIETRQDGVRCVIVPNDQMETPHYHVLRVRKGEETPTLS
YMLPKLHEEA
3D structure
PDB5f6c Substrate Recognition and Autoinhibition in the Central Ribonuclease RNase E.
ChainB
Resolution3.002 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.12: ribonuclease E.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B S121 V128 G137 I139 S140 R142 I167 R169 T170 S122 V129 G138 I140 S141 R143 I168 R170 T171
BS02 MG B D28 S393 D29 S394
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004540 RNA nuclease activity
GO:0008995 ribonuclease E activity
Biological Process
GO:0006396 RNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:5f6c, PDBe:5f6c, PDBj:5f6c
PDBsum5f6c
PubMed30270108
UniProtP21513|RNE_ECOLI Ribonuclease E (Gene Name=rne)

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