Structure of PDB 5f1c Chain B

Receptor sequence
>5f1cB (length=355) Species: 34609 (Amblyomma maculatum) [Search protein sequence]
GSREFDQKIGVLNRLIQLLILGYIIGYVIIYQKGYQQFSTFNAATTTKVK
GVVSTKNLSDDAFYPFLSDKTVYKRVWDIADIVVPPEESNQFFVTTNLII
TPSQEIKTCPEDPSIKEAHCKSENDTTSCTAGKSIMIGNGVMTGRCVQAA
KPQETLHVCEISGWCPVEQDYGPLKDGTPLLSDVQNFTVLIKNYIEFSLF
HVRRSNLHDIENSTYLKYCRYHPEKDPHCPVFRIGDMVDAAGEDFDDVAA
KGGVIQVLISWDCNLDYDVKYCIPNYSFLRLDDPKTVLAKGWNFRYPKYY
NEKERSLVKAYGITFVILVQGRAGKLSPIPIAINIGSGLGLMVVATVLCD
LVVLN
3D structure
PDB5f1c Structural Insights into Divalent Cation Modulations of ATP-Gated P2X Receptor Channels
ChainB
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP B K66 K68 T206 L208 K48 K50 T188 L190 PDBbind-CN: -logKd/Ki=6.13,Kd=0.745uM
BS02 ZN B E214 H219 E196 H201
BS03 ZN B G19 D24 G1 D6
BS04 ATP B D188 N311 R313 K327 D170 N293 R295 K309 PDBbind-CN: -logKd/Ki=6.13,Kd=0.745uM
Gene Ontology
Molecular Function
GO:0001614 purinergic nucleotide receptor activity
GO:0004931 extracellularly ATP-gated monoatomic cation channel activity
GO:0005524 ATP binding
GO:0015267 channel activity
GO:0046872 metal ion binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0007165 signal transduction
GO:0033198 response to ATP
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0060079 excitatory postsynaptic potential
GO:0070588 calcium ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0098794 postsynapse

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Cellular Component
External links
PDB RCSB:5f1c, PDBe:5f1c, PDBj:5f1c
PDBsum5f1c
PubMed26804916
UniProtG3MM57

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