Structure of PDB 5f0q Chain B

Receptor sequence
>5f0qB (length=185) Species: 9606 (Homo sapiens) [Search protein sequence]
ISLDQIDLLSTKSFPPCMRQLHKALRENHHLRHGGRMQYGLFLKGIGLTL
EQALQFWKQEFIKGKMDPDKFDKGYSYNIRHSFGKEGKRTDYTPFSCLKI
ILSNPPSQGDYHGCPFRHSDPELLKQKLQSYKISPGGISQILDLVKGTHY
QVACQKYFEMIHNVDDCGFSLNHPNQFFCESQRIL
3D structure
PDB5f0q Mechanism of Concerted RNA-DNA Primer Synthesis by the Human Primosome.
ChainB
Resolution2.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B H300 R302 H303 R306 Y345 H30 R32 H33 R36 Y75
BS02 dna B H303 M307 K343 Y347 H351 K358 T360 Y362 T363 F365 S366 K369 H33 M37 K73 Y77 H81 K88 T90 Y92 T93 F95 S96 K99
BS03 SF4 B P285 C287 C367 C384 C424 L441 P444 P15 C17 C97 C114 C154 L171 P174
Gene Ontology
Biological Process
GO:0006269 DNA replication, synthesis of primer

View graph for
Biological Process
External links
PDB RCSB:5f0q, PDBe:5f0q, PDBj:5f0q
PDBsum5f0q
PubMed26975377
UniProtP49643|PRI2_HUMAN DNA primase large subunit (Gene Name=PRIM2)

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