Structure of PDB 5ey8 Chain B

Receptor sequence
>5ey8B (length=594) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
QIKFPDGSSIVAHVERWAKVRGDKLAYRFLDFSTGVPRDLTWAQFSARNR
AVAARLQQVTQPGDRVAILCPQNLDYLVAFFGALYAGRIAVPLFDPSGHV
GRLHAVLDNCHPSAILTTTEAAEGVRKFFRTRPANQRPRVIAVDAVPDDV
ASTWVNPDEPDETTIAYLQYTSGSTRIPTGVQITHLNLATNVVQVIEALE
GEEGDRGLSWLPFFHDMGLITALLAPMIGHYFTFMTPAAFVRRPERWIRE
LARKEGDTGGTISVAPNFAFDHAAARGVPKPGSPPLDLSNVKAVLNGSEP
ISAATVRRFNEAFGPFGFPPKAIKPSYGLAEATLFVSTTPSAEEPKIITV
DRDQLNSGRIVEVDADSPKAVAQASAGKVGIAEWAVIVDAESATELPDGQ
VGEIWISGQNMGTGYWGKPEESVATFQNILKSRTNPSHAEGATDDATWVR
TGDYGAFYDGDLYITGRVKDLVIIDGRNHYPQDLEYSAQEASKAIRTGYV
AAFSVPANQLPDEVFENAHSGIKRDPDDTSQLVIVAERLDIGPITDDIRA
AIAVRHGVTVRDVLLTAAGAIPRTSSGKIGRRACRAAYLDGSLR
3D structure
PDB5ey8 Insight into Structure-Function Relationships and Inhibition of the Fatty Acyl-AMP Ligase (FadD32) Orthologs from Mycobacteria.
ChainB
Resolution3.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N207 H231 A346
Catalytic site (residue number reindexed from 1) N191 H215 A330
Enzyme Commision number 6.2.1.20: long-chain-fatty-acid--[acyl-carrier-protein] ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5SV B H231 D232 M233 T237 L311 S314 P316 Y343 G344 L345 L350 D469 H215 D216 M217 T221 L295 S298 P300 Y327 G328 L329 L334 D453
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008922 long-chain fatty acid [acyl-carrier-protein] ligase activity
GO:0016874 ligase activity
GO:0070566 adenylyltransferase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0008610 lipid biosynthetic process
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ey8, PDBe:5ey8, PDBj:5ey8
PDBsum5ey8
PubMed26900152
UniProtA0R618|FAA32_MYCS2 Long-chain-fatty-acid--AMP ligase FadD32 (Gene Name=fadD32)

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