Structure of PDB 5ey3 Chain B

Receptor sequence

>5ey3B (length=440) Species: 99287 (Salmonella enterica subsp. enterica serovar Typhimurium str. LT2)

MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHD
MTMPERVSLTMAMRDSGTVLDWKSLNLNGPIVDKHSTGGVGDVTSLMLGP
MVAACGGYVPMISGRGLGHTGGTLDKLEAIPGFDIFPDDNRFREIIQDVG
VAIIGQTSSLAPADKRFYATRDITATVDSIPLITGSILAKKLAEGLDALV
MDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSA
GNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGQLAKDDAEARAKL
QAVLDNGKAAEVFGRMVAAQKGPSDFVENYDKYLPTAMLSKAVYADTEGF
ISAMDTRALGMAVVSMGGGRRQASDTIDYSVGFTDMARLGDSIDGQRPLA
VIHAKDEASWQEAAKAVKAAIILDDKAPASTPSVYRRITE

3D structure

• PDB: 5ey3 X-ray structure of the thymidine phosphorylase from Salmonella typhimurium in complex with cytidine and sulphate
• Chain: B
• Resolution: 1.905 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D83 K84 H85 S86 T123 D164 R171 S186 K190 K191
• Catalytic site (residue number reindexed from 1): D83 K84 H85 S86 T123 D164 R171 S186 K190 K191
• Enzyme Commision number: 2.4.2.4: thymidine phosphorylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CTN	B	D50 R56 I180 A219	D50 R56 I180 A219

Gene Ontology

Molecular Function

• GO:0004645 1,4-alpha-oligoglucan phosphorylase activity
• GO:0009032 thymidine phosphorylase activity
• GO:0016154 pyrimidine-nucleoside phosphorylase activity
• GO:0016757 glycosyltransferase activity
• GO:0016763 pentosyltransferase activity

Biological Process

• GO:0006206 pyrimidine nucleobase metabolic process
• GO:0006213 pyrimidine nucleoside metabolic process
• GO:0046104 thymidine metabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:5ey3, PDBe:5ey3, PDBj:5ey3
• PDBsum: 5ey3
• UniProt: Q7CP66|TYPH_SALTY Thymidine phosphorylase (Gene Name=deoA)