Structure of PDB 5ewj Chain B

Receptor sequence
>5ewjB (length=353) Species: 9606 (Homo sapiens) [Search protein sequence]
PPSIGIAVILVGTSDEVAIKDLSVVPRVELVAMNETDPKSIITRICDLMS
DRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDES
SMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTI
ENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYI
FEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLP
ARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLI
NVTFEGRDLSFSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYV
WPR
3D structure
PDB5ewj A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists.
ChainB
Resolution2.77 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QEL B Q110 I111 F114 F176 E236 Q70 I71 F74 F136 E196 PDBbind-CN: -logKd/Ki=6.89,IC50=130nM
BindingDB: Ki=10.0nM,Kd=7.6nM,IC50=110nM
External links
PDB RCSB:5ewj, PDBe:5ewj, PDBj:5ewj
PDBsum5ewj
PubMed26912815
UniProtQ13224|NMDE2_HUMAN Glutamate receptor ionotropic, NMDA 2B (Gene Name=GRIN2B)

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