Structure of PDB 5euj Chain B

Receptor sequence
>5eujB (length=555) Species: 33074 (Zymobacter palmae) [Search protein sequence]
MYTVGMYLAERLAQIGLKHHFAVAGDYNLVLLDQLLLNKDMEQVYCCNEL
NCGFSAEGYARARGAAAAIVTFSVGAISAMNAIGGAYAENLPVILISGSP
NTNDYGTGHILHHTIGTTDYNYQLEMVKHVTCAAESIVSAEEAPAKIDHV
IRTALRERKPAYLEIACNVAGAECVRPGPINSLLRELEVDQTSVTAAVDA
AVEWLQDRQNVVMLVGSKLRAAAAEKQAVALADRLGCAVTIMAAAKGFFP
EDHPNFRGLYWGEVSSEGAQELVENADAILCLAPVFNDYATVGWNSWPKG
DNVMVMDTDRVTFAGQSFEGLSLSTFAAALAEKAPSRPATTQGTQAPVLG
IEAAEPNAPLTNDEMTRQIQSLITSDTTLTAETGDSWFNASRMPIPGGAR
VELEMQWGHIGWSVPSAFGNAVGSPERRHIMMVGDGSFQLTAQEVAQMIR
YEIPVIIFLINNRGYVIEIAIHDGPYNYIKNWNYAGLIDVFNDEDGHGLG
LKASTGAELEGAIKKALDNRRGPTLIECNIAQDDCTETLIAWGKRVAATN
SRKPQ
3D structure
PDB5euj Crystal structure of pyruvate decarboxylase from Zymobacter palmae.
ChainB
Resolution2.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G25 D26 Y27 N28 E49 T71 H112 H113 I115 G116 C167 E263 A290 E382 T383 G408 D435 N462 G464 I467 E468
Catalytic site (residue number reindexed from 1) G25 D26 Y27 N28 E49 T71 H112 H113 I115 G116 C167 E263 A290 E382 T383 G408 D435 N462 G464 I467 E468
Enzyme Commision number 4.1.1.1: pyruvate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TPP B A24 E49 V74 H113 A24 E49 V74 H113
BS02 MG B D435 N462 G464 D435 N462 G464
BS03 TPP B G384 D385 G408 H409 I410 G434 G436 S437 N462 G464 Y465 V466 I467 E468 G384 D385 G408 H409 I410 G434 G436 S437 N462 G464 Y465 V466 I467 E468
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004737 pyruvate decarboxylase activity
GO:0016831 carboxy-lyase activity
GO:0030976 thiamine pyrophosphate binding
GO:0046872 metal ion binding
Biological Process
GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway
GO:0019752 carboxylic acid metabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5euj, PDBe:5euj, PDBj:5euj
PDBsum5euj
PubMed27599861
UniProtQ8KTX6

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