Structure of PDB 5epo Chain B

Receptor sequence
>5epoB (length=261) Species: 29369 (Clostridium sardiniense) [Search protein sequence]
KRLEGKVAIVTSSTRGIGRASAEALAKEGALVYLAARSEELANEVIADIK
KQGGVAKFVYFNAREEETYTSMVEKVAEAEGRIDILVNNYGGTNVNLDKN
LTAGDTDEFFRILKDNVQSVYLPAKAAIPHMEKVGGGSIVNISTIGSVVP
DISRIAYCVSKSAINSLTQNIALQYARKNIRCNAVLPGLIGTRAALENMT
DEFRDSFLGHVPLNRVGRPEDIANAVLYYASDDSGYVTGMIHEVAGGFAL
GTPQYSEYCPR
3D structure
PDB5epo The three-dimensional structure of Clostridium absonum 7 alpha-hydroxysteroid dehydrogenase: new insights into the conserved arginines for NADP(H) recognition
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G17 T145 I153 Y158 K162 R194
Catalytic site (residue number reindexed from 1) G16 T144 I152 Y157 K161 R193
Enzyme Commision number 1.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP B S13 T15 R16 G17 I18 R38 F62 N63 A64 N90 G92 Y158 P188 I191 T193 R194 A195 A196 S12 T14 R15 G16 I17 R37 F61 N62 A63 N89 G91 Y157 P187 I190 T192 R193 A194 A195
BS02 TUD B G93 T94 T145 Y158 G189 N199 M200 F204 G92 T93 T144 Y157 G188 N198 M199 F203
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
Biological Process
GO:0016042 lipid catabolic process
GO:0030573 bile acid catabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5epo, PDBe:5epo, PDBj:5epo
PDBsum5epo
PubMed26961171
UniProtG9FRD7|HDHA_CLOSR 7alpha-hydroxysteroid dehydrogenase (Gene Name=hdha)

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