Structure of PDB 5ejv Chain B

Receptor sequence
>5ejvB (length=245) Species: 9606 (Homo sapiens) [Search protein sequence]
YASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSM
WEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLV
RMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFS
EDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSIL
AKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFST
3D structure
PDB5ejv Discovery of biaryls as ROR gamma inverse agonists by using structure-based design.
ChainB
Resolution2.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B K336 I350 K354 P500 E504 K73 I87 K91 P237 E241
BS02 444 B W317 C320 M365 I397 I400 H479 W54 C57 M102 I134 I137 H216 BindingDB: IC50=60nM,EC50=54nM,Ki=51nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ejv, PDBe:5ejv, PDBj:5ejv
PDBsum5ejv
PubMed27080181
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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