Structure of PDB 5egu Chain B

Receptor sequence
>5eguB (length=116) Species: 9606 (Homo sapiens) [Search protein sequence]
PNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIK
TPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEA
LEKLFLQKINELPTEE
3D structure
PDB5egu Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins.
ChainB
Resolution2.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5NQ B P82 F83 Q85 V87 D88 L92 L94 N140 P30 F31 Q33 V35 D36 L40 L42 N88 MOAD: Kd=1.4uM
BindingDB: IC50=5000nM,Kd=1400nM
External links
PDB RCSB:5egu, PDBe:5egu, PDBj:5egu
PDBsum5egu
PubMed26735842
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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